Pastor West's sermon, "What Are the Odds: 1 out of 10," focuses on gratitude using the story of the ten healed lepers in Luke 17. He emphasizes rejoicing in God's goodness and the importance of expressing gratitude. Pastor West highlights the one leper who returned to thank Jesus, stressing the value of vocalizing gratitude. The sermon challenges us to be thankful in all circumstances and always remember to thank God for His blessings.